Synthesis of 13C-labelled, bicyclic mimetics of natural enediynes
نویسندگان
چکیده
منابع مشابه
Synthesis of 13C-labelled, bicyclic mimetics of natural enediynes.
Using a versatile synthesis with 13CH3PPh3I and CH(3)13CO2Et as 13C sources, the first examples of nine-membered chromophores which have been differentially labelled with 13C in their carbocyclic enediyne cores are described.
متن کاملThe Use of 13C in the Synthesis of Double Labelled Precursors
Discovery of 13C NMR and its application in the biosynthetic pathways prompted the synthesis of several 13C labelled precursors. To investigate the metabolism of phenyllactic acid in the Solanaceae family, the double labelled acid was synthesized from barium carbonate (13C) and sodium syanide (13C)
متن کاملSynthesis of bicyclic enediynes that possess a photosensitive triggering device and exhibit strong DNA cleaving activity.
The synthesis of a bicyclic enediyne capable of photosensitive triggering and conjugated to a pyrrole-imidazole polyamide is described. Using UV irradiation, this hybrid molecule is shown to exhibit 100-fold stronger potency for DNA cleavage, in an in vitro assay, as compared to the enediyne without the DNA-localizing pyrrole-imidazole.
متن کاملthe use of 13c in the synthesis of double labelled precursors
discovery of 13c nmr and its application in the biosynthetic pathways prompted the synthesis of several 13c labelled precursors. to investigate the metabolism of phenyllactic acid in the solanaceae family, the double labelled acid was synthesized from barium carbonate (13c) and sodium syanide (13c)
متن کاملcomparison of catalytic activity of heteropoly compounds in the synthesis of bis(indolyl)alkanes.
heteropoly acids (hpa) and their salts have advantages as catalysts which make them both economically and environmentally attractive, strong br?nsted acidity, exhibiting fast reversible multi-electron redox transformations under rather mild conditions, very high solubility in polar solvents, fairly high thermal stability in the solid states, and efficient oxidizing ability, so that they are imp...
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ژورنال
عنوان ژورنال: Chemical Communications
سال: 2002
ISSN: 1359-7345,1364-548X
DOI: 10.1039/b208939d